Heparan-Sulfate Proteoglycans Influence Alzheimer's Disease Cell Pathology

Researchers utilized mouse astrocytes and human cell cultures to investigate how HSPGs influence autophagy, mitochondrial function, and lipid synthesis.

They also explored whether altering HSPG signaling could mitigate the effects of mutated presenilin (PSEN1) in Drosophila models.

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As professionals in Clinical Research Courses explore the parallels between autophagy's meticulous cellular cleanup and the precision required in clinical research
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This gene produces a protein that controls autophagy, a starvation-induced catabolic process of destruction. The encoded protein functions as a part of the vesicle-trafficking processes-mediating phosphatidylinositol-3-kinase (PI3K) complex. This protein is believed to be involved in a number of cellular processes, such as apoptosis, neurodegeneration, and cancer. There are various transcript variations produced by alternative splicing.
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The PINK1 gene (encoding the PINK1 protein) is a known pathogenic variant gene that causes PD. A large number of in vitro and biochemical experiments have shown that PINK1 protects neuronal cells by inducing autophagy of damaged mitochondria, and loss of PINK1 function leads to neuronal cell death in PD. Learn more, https://neuros.creative-bi...