NCI-H82 is an epithelioid cell line isolated from the lung of a 40-year-old Caucasian male with lung cancer. The cell line was isolated in 1978 by A.F. Gazdar and colleagues from the pleural effusion of a patient with small cell lung cancer. The morphology of the original tumor does not conform to the characteristics of small cell lung cancer (SCLC).

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McA-RH7777 is a cell with epithelial-like morphology that was isolated from the liver of female rats with hepatocellular carcinoma. These cells exhibit adherent growth with a distinctive fusiform and polygonal appearance. They induce subcutaneous tumors in rats following subcutaneous injection of MCA-RH 7777.

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The T84 cell line is a transplantable human cancer cell line derived from a lung metastasis of colon cancer in a 72-year-old male. T84 cells spontaneously differentiate into a structurally and functionally mature absorptive epithelial monolayer upon confluence. This maturation is complete over a period of 2-3 weeks and monolayer integrity is routinely assessed by measuring transepithelial electrical resistance (TEER).

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CRISPR/Cas9 PlatformCB is a professional genetic editing biotechnology company that provides transgenic mouse models for biomedical research and drug discovery. We will provide you with a one-stop-shop from experimental design strategies to successful mouse model generation. The CRISPR/Cas9 platformCB offers CRISPR-based knock-in mice at a very competitive price and complete in 3-4 months. We guarantee delivery of at least 2 founders or 3 F1 animals for knockin.

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Creative Biogene CRISPR/Cas9 Platform provides comprehensive gene editing services for various cell lines, especially for primary T cells. With years of experience, our talented scientists have established an efficient assay to edit genome in T cells by CRISPR/Cas9. At CRISPR/Cas9 PlatformCB, we offer a gene knockout service for customer as well as isolation of primary T cell service. Based on our excellent platform, our staff are focusing on supplying the best services and products.

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CRISPR/Cas9 system is one of the most common used gene-editing tools, which was first described as an immune defense system. Considering its easy-to-use, simple-to-design and multiplexed engineering, CRISPR/Cas9 is widely used for genome engineering in microbes, mammalian cells/models and plants. However, the inefficiency of precise base editing and off-target activities remains. To get rid of this situation, base editing is developed as a new genome editing technology, which can be widely used in mammalian cells, plants, microbes and model organisms. Base editing enables the irreversible conversion of a specific DNA base into another at a targeted genomic locus, for example conversing C to T, or A to G. Unlike other genome-editing tools, base editing can be achieved without double-strand breaks. When introducing a point mutation at a target locus, base editing is more efficient than traditional genome editing techniques. Since many genetic diseases arise from point mutations, base editing has important applications in disease research.

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Creative Biogene is developing stable cell lines overexpressing human / mouse/ rat miRNA precursors covered in the current miRbase. Our miRNA overexpression stable cell lines are constructed by lentivirus transduction or non-viral plasmid transfection of vectors optimized by our scientists to enable expression and maturation of miRNAs inside cells. These cell lines are valuable tools for studying miRNA gain-of-functions and identifying the potential target genes.

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Creative Biogene provides world-class MicroRNA (miRNA) sponge service and we have been perfecting MicroRNA sponge service for many years. Our microRNA sponge is a RNA molecule with 5-8 tandem miRNA binding sequences that can sequester miRNAs from their endogenous target mRNAs.

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Creative Biogene delivers an extensive portfolio of recombinant drug target proteins with exceptional batch-to-batch consistency, leveraging advanced expression systems and optimized post-translational modifications. Our comprehensive protein collection, manufactured under global pharmacopeia standards and supported by a traceable supply chain, ensures reliable delivery of premium-grade products that meet diverse requirements across the drug development pipeline, from research to GMP-grade levels.

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The application of viral vectors in gene therapy is rapidly developing and the therapeutic results are highly promising. However, actively and passively integrating (viral) vectors may fail to deliver, or trigger severe side effects by undirected or unintended integration into the genome of the target cell. Thus, the analysis of vector integration sites in target cells is extremely important to address both biological and safety issues. Creative Biogene, as one of the leading biotechnology companies, has extensive expertise and experience which are available to provide you with customer LAM PCR service to analyze the viral vector insertion/integration site.

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