Creative Biogene, a zebrafish research company with experienced scientists and advanced technology, can offer multiple gene-editing services including but not limited to point mutations, knockout, short insertions, gene knock-in and conditional knock-in. We use CRISPR-Cas9 (Tol2 available) as our genome editing methods. Our service can significantly reduce your experiment time and can be tailored to different experimental requirements.
https://zebrafish.creative...
https://zebrafish.creative...
02:37 AM - Jul 25, 2025 (UTC)
Zebrafish is not only an ideal model in developmental biology research but also for the examination of organ toxicity. With years of experience and advanced technologies, Creative Biogene has developed several approaches to utilize zebrafish in nephrotoxicity screening. We have examined the feasibility of zebrafish as an alternative animal model to mammals for evaluating DIKI. And we have improved this screening assay and technology, and performed a large in vivo high-content screening experiment with the aim to identify approved drugs with adverse effects on the kidney in zebrafish.
https://zebrafish.creative...
https://zebrafish.creative...
02:36 AM - Jul 25, 2025 (UTC)
Zebrafish cancer models are rapidly gaining popularity and yielding clinically translatable insights. The zebrafish model system has several advantages over other animal models. Their high fecundity and low rearing costs allow for extensive genetic screening. Zebrafish are transparent and develop externally, allowing in vivo imaging and analysis of normal organogenesis mechanisms. In addition, small molecule drugs can be added directly to zebrafish water. If a larval stage phenotype is discovered, high-throughput chemical screening of the whole organism can be performed to identify relevant signaling pathways and evaluate potential mechanisms of molecular intervention.
https://zebrafish.creative...
https://zebrafish.creative...
02:35 AM - Jul 25, 2025 (UTC)
NCI-H82 is an epithelioid cell line isolated from the lung of a 40-year-old Caucasian male with lung cancer. The cell line was isolated in 1978 by A.F. Gazdar and colleagues from the pleural effusion of a patient with small cell lung cancer. The morphology of the original tumor does not conform to the characteristics of small cell lung cancer (SCLC).
https://www.creative-bioge...
https://www.creative-bioge...
07:58 AM - Jun 24, 2025 (UTC)
McA-RH7777 is a cell with epithelial-like morphology that was isolated from the liver of female rats with hepatocellular carcinoma. These cells exhibit adherent growth with a distinctive fusiform and polygonal appearance. They induce subcutaneous tumors in rats following subcutaneous injection of MCA-RH 7777.
https://www.creative-bioge...
https://www.creative-bioge...
07:57 AM - Jun 24, 2025 (UTC)
The T84 cell line is a transplantable human cancer cell line derived from a lung metastasis of colon cancer in a 72-year-old male. T84 cells spontaneously differentiate into a structurally and functionally mature absorptive epithelial monolayer upon confluence. This maturation is complete over a period of 2-3 weeks and monolayer integrity is routinely assessed by measuring transepithelial electrical resistance (TEER).
https://www.creative-bioge...
https://www.creative-bioge...
07:56 AM - Jun 24, 2025 (UTC)
CRISPR/Cas9 PlatformCB is a professional genetic editing biotechnology company that provides transgenic mouse models for biomedical research and drug discovery. We will provide you with a one-stop-shop from experimental design strategies to successful mouse model generation. The CRISPR/Cas9 platformCB offers CRISPR-based knock-in mice at a very competitive price and complete in 3-4 months. We guarantee delivery of at least 2 founders or 3 F1 animals for knockin.
https://www.creative-bioge...
https://www.creative-bioge...
09:51 AM - May 29, 2025 (UTC)
Creative Biogene CRISPR/Cas9 Platform provides comprehensive gene editing services for various cell lines, especially for primary T cells. With years of experience, our talented scientists have established an efficient assay to edit genome in T cells by CRISPR/Cas9. At CRISPR/Cas9 PlatformCB, we offer a gene knockout service for customer as well as isolation of primary T cell service. Based on our excellent platform, our staff are focusing on supplying the best services and products.
https://www.creative-bioge...
https://www.creative-bioge...
09:50 AM - May 29, 2025 (UTC)
CRISPR/Cas9 system is one of the most common used gene-editing tools, which was first described as an immune defense system. Considering its easy-to-use, simple-to-design and multiplexed engineering, CRISPR/Cas9 is widely used for genome engineering in microbes, mammalian cells/models and plants. However, the inefficiency of precise base editing and off-target activities remains. To get rid of this situation, base editing is developed as a new genome editing technology, which can be widely used in mammalian cells, plants, microbes and model organisms. Base editing enables the irreversible conversion of a specific DNA base into another at a targeted genomic locus, for example conversing C to T, or A to G. Unlike other genome-editing tools, base editing can be achieved without double-strand breaks. When introducing a point mutation at a target locus, base editing is more efficient than traditional genome editing techniques. Since many genetic diseases arise from point mutations, base editing has important applications in disease research.
https://www.creative-bioge...
https://www.creative-bioge...
09:50 AM - May 29, 2025 (UTC)
Creative Biogene is developing stable cell lines overexpressing human / mouse/ rat miRNA precursors covered in the current miRbase. Our miRNA overexpression stable cell lines are constructed by lentivirus transduction or non-viral plasmid transfection of vectors optimized by our scientists to enable expression and maturation of miRNAs inside cells. These cell lines are valuable tools for studying miRNA gain-of-functions and identifying the potential target genes.
https://www.creative-bioge...
https://www.creative-bioge...
08:47 AM - Feb 21, 2025 (UTC)
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