Zebrafish is not only an ideal model in developmental biology research but also for the examination of organ toxicity. With years of experience and advanced technologies, Creative Biogene has developed several approaches to utilize zebrafish in nephrotoxicity screening. We have examined the feasibility of zebrafish as an alternative animal model to mammals for evaluating DIKI. And we have improved this screening assay and technology, and performed a large in vivo high-content screening experiment with the aim to identify approved drugs with adverse effects on the kidney in zebrafish.

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