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How Scientists Build Point Mutation Cell Lines: An Overview of Current Strategies
In modern biomedical research, the ability to model human disease at the cellular level has become increasingly crucial. With the advent of next-generation sequencing (NGS), thousands of disease-associated single nucleotide polymorphisms (SNPs) have been identified. To explore the biological consequences of these variants, researchers often rely on point mutation cell line construction to introduce precise, predefined mutations into the genome.
For researchers looking to build such models, there are several gene editing strategies to consider. Each has its own benefits and challenges, and the best choice often depends on the target site, mutation type, and available resources.
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03:27 AM - May 29, 2025 (UTC)

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