The GL261 cell line, derived from a chemically induced glioma in C57BL/6 mice, has become a cornerstone model in glioblastoma (GBM) research. Its unique ability to grow in immunocompetent hosts sets it apart from human glioma models, allowing exploration of tumor-immune interactions in syngeneic mouse systems.
In this article, we’ll dive into GL261’s biological characteristics, culture practices, common troubleshooting, and gene editing considerations—equipping researchers with practical knowledge to support reliable and reproducible glioma studies.
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