The SH-SY5Y cell line is a human neuroblastoma cell line commonly used in neuroscience research to study neurodevelopment, neurodegenerative diseases, and neurotoxicity. The SH-SY5Y cell line was derived from a bone marrow biopsy of a 4-year-old female with neuroblastoma. SH-SY5Y was cloned from the bone marrow biopsy-derived line SK-N-SH by the laboratory of June Biedler and first reported in 1973. A neuroblast-like subclone of SK-N-SH, termed SH-SY, was subcloned as SH-SY5, and a third subcloning resulted in the SH-SY5Y line, first described in 1978.

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