Drug-resistant cell models are needed to investigate the mechanisms underlying drug resistance acquisition in cancer cells in order to develop hypotheses that can be tested by the use of clinical material. Researchers use drug-resistant cell models to mimic the conditions cancer patients experience during chemotherapy, and to understand potential mechanisms of resistance to chemotherapy agents. However, the reference regarding the methodology of the development process is little, and exploring a suitable selection strategy and finally generating stably drug-resistant cell model in house can be very time- and energy- consuming.

https://www.creative-bioar...