Our services not only include hERG inhibition testing but also cover inhibitory assessments of potassium, calcium, and sodium channels, as well as other related channels or receptors. Additionally, we provide "Comprehensive Cardiotoxicity Assessment (CiPA)" and "Langendorff Isolated Perfused Heart Assay" services. These comprehensive and precise assessment methods enable the evaluation of your drug's in vitro cardiotoxicity potential, thereby reducing the risk of development failure due to cardiac safety issues, and consequently minimizing economic losses.

https://www.creative-bioar...

Hepatocytes in 3D culture are the proper culture models for testing the liver-specific functions in vitro. The functional parameters such as CYP activity, ATP, albumin production, and enzyme content, etc., will be measured based on the customers’ choices. Albumin and urea are synthesized by the liver. As so, they are markers for the ability of the liver to synthesize proteins. CYPs are involved in the metabolism of drugs, chemicals and endogenous substrates. CYP-mediated activation of drugs to toxic metabolites induces hepatotoxicity. Thus, a wide range of assays for liver in vitro models will evaluate your compounds by characterization hepatic functions and their drug-mediated responses.

https://www.creative-bioar...

IHC, by exploiting the principle of antibodies binding specifically to antigens in biological tissues, is a routine method to detect antigens in cells of a tissue section. It is widely used in the diagnosis of diseases including cancer, neurological disease, digestive disease, etc. Specific molecular markers have been found and verified to be characteristic of particular cellular events in disease such as proliferation, apoptosis and inflammation. Thus it could be used in detection of such changes involved in disease. IHC is also a common method in basic research of disease to help understanding the distribution and localization of biomarkers and differentially expression of proteins in different parts of tissue. Creative Bioarray offers a comprehensive IHC service from project design, marker selection to image completion and data analysis. We are dedicated to satisfied every customer and assist them to achieve their specific research goals.

https://www.creative-bioar...

The animal models of human diseases are animal experimental objects and materials established in biomedical scientific research with the mimicry of human diseases. The use of animal models is an important experimental method and means in modern biomedical research, which helps to more conveniently and effectively understand the occurrence, development, and prevention measures of human diseases.

https://www.creative-bioar...

Creative Bioarray is an experienced and outstanding provider of cell-based Screening and profiling Services including cell-based high-throughput and high-content screening, specificity and selectivity profiling, and dose-response analysis. With our experienced scientific team and advanced technologies, we are able to quickly narrow down a large pool of candidates and identify effective compounds.

https://www.creative-bioar...

Creative Bioarray is dedicated to providing premier syngeneic mouse model services, crafted to be an indispensable tool for the initial assessment of innovative immunotherapies-including vaccines, mRNA therapies, immune checkpoint inhibitors, antibody-drug conjugates, and cellular therapies like CAR-T and NK cell treatments, as well as traditional anti-cancer modalities such as chemotherapy and radiotherapy. Our unwavering commitment to excellence guarantees that these models are not only of superior quality but also customized to address the varied requirements of our clients, thereby accelerating progress in cancer research and therapeutic innovation.

https://www.creative-bioar...

Blood and blood cell components include whole blood, serum or plasma, red blood cells and white blood cells. We can also provide lymphocytes, including B cells, T cells, and NK cells. All blood is collected by certified phlebotomists and blood processing is performed according to strict standard operating procedures.

https://www.histobiolab.co...

Histological staining plays a critical role in the visualization of tissue and cell structures. Living cells or fixed cells have very few inherent colors and only very small differences in the refractive indices of their component parts. By staining tissue sections, pathologists and researchers can view tissue morphology (structure) or look for the presence or prevalence of particular cell types, structures or even micro-organisms under a microscope.

Histological staining includes routine staining and special staining. Routine staining refers primarily to the hematoxylin and eosin (H&E) stain, while special staining is used to refer to alternative staining techniques outside of routine H&E stain to provide specific information researchers or pathologists need.

https://www.histobiolab.co...

ISH differs from immunohistochemistry which typically localizes proteins in tissue sections. ISH can be performed on a variety of targets, including RNA within cells, DNA in metaphase chromosome preparations obtained from mitotic cells, or DNA in interphase nuclei from cells in the non-mitotic phases. ISH not only has the advantages of detection in morphological context, but also is favored by people for its high sensitivity to nucleic acid detection. ISH has been widely used in clinical cytogenetics, tumor biology, gene mapping and chromosome evolution research.

https://www.histobiolab.co...

Electron microscopes can be divided into transmission electron microscopes, scanning electron microscopes, reflection electron microscopes and emission electron microscopes according to their structure and purpose.

Creative Bioarray has many years of experience in electron microscopy services, and can provide customers with technical services for electron microscopy testing of various samples.

https://www.histobiolab.co...