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prachi cmi @prachicmi
10 days ago
Second Generation Antipsychotics: Efficacy, Safety, and Clinical Applications

Antipsychotic medications have been a cornerstone in the treatment of various psychiatric disorders, particularly schizophrenia and bipolar disorder. The development of second generation antipsychotics (SGAs), also known as atypical antipsychotics, has revolutionized the management of these conditions, offering improved efficacy and safety profiles compared to their first generation counterparts.

The introduction of Second Generation Antipsychotics in the 1990s marked a significant advancement in the treatment of psychiatric disorders. These medications were developed to address the limitations of first generation antipsychotics (FGAs).

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01:43 PM - May 08, 2025 (UTC)
prachi cmi @prachicmi
6 months ago
Antipsychotic Drugs: Mechanisms of Action and Clinical Uses

Antipsychotic Drugs work by blocking dopamine receptors, particularly D2 receptors, in the brain. Dopamine is a neurotransmitter that plays a key role in psychosis. By blocking its receptors, antipsychotics reduce dopamine's excitatory effects and balance out its activity. The dopamine receptor D2 is an important mediator of neurological and behavioral functions and it is implicated in psychosis when it overstimulated. Antipsychotics decrease dopamine receptor stimulation, which in turn reduces psychotic symptoms.

In addition to blocking dopamine receptors, some antipsychotics also block serotonin receptors, histamine receptors, and alpha-adrenergic receptors. This multi-receptor action contributes to their effectiveness against psychosis as well as side effects. Newer "atypical" antipsychotics are less likely than older drugs to block dopamine and serotonin receptors, providing similar effectiveness against psychosis with a lower risk of extrapyramidal symptoms.
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11:23 AM - Nov 04, 2024 (UTC)

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