In addition, RBCs contain a variety of enzymes that can metabolize many drugs. Thus, the processing of blood samples should be done in accord with a protocol that is based on the results of previous studies, establishing the interaction between RBCs and the drug being developed. Sample protocols should specify the centrifugation time, temperature, and pH conditions, as well as need for addition of enzyme inhibitors. At Creative Bioarray, the red blood cell partitioning assay provides a specific and robust approach to assess these parameters using fresh blood from human and preclinical species.

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Certain types of drug molecules, such as those containing ester or amide-linked groups are prone to enzymatic hydrolysis by plasma esterases, amidases or proteases. On the other hand, enzymatic activation of some prodrugs that takes place in plasma is critical for their function. Hence, plasma enzymes can significantly alter the bioavailability of the active compounds, and therefore determination of the compound stability in plasma has both pharmacokinetic and clinical significance.

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Creative Bioarray offers comprehensive in vitro ADME services for drug discovery organizations. Many of our in vitro ADME assays come in a variety of formats to suit different stages of the drug discovery pipeline, enabling us to provide a flexible approach to our ADME services. While Creative Bioarray has standard procedures for each of these assays listed below, our experienced research team can also help design the best strategies and protocols customized to meet any drug discovery needs.

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Mouse Retinal Pigment Epithelial Cells are isolated from mouse tissues. Mouse Retinal Pigment Epithelial Cells are cryopreserved at P0 and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. Mouse Retinal Pigment Epithelial Cells are negative for mycoplasma, bacteria, yeast, and fungi. Mouse Retinal Pigment Epithelial Cells are guaranteed to further expand for 5 population doublings under the conditions provided by Creative Bioarray.

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HSF from Creative Bioarray are isolated from human spleen tissue. HSF are cryopreserved at primary culture and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HSF are characterized by their spindle morphology and immunofluorescent method with antibody to fibronectin. HSF are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HSF are guaranteed to further expand for 15 population doublings at the condition provided byCreative Bioarray.

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Canine Small Intestinal Epithelial Cells from Creative Bioarray are isolated from small intestinal tissue of pathogen-free laboratory Canine. Canine Small Intestinal Epithelial Cells are grown in a T25 tissue culture flask pre-coated with gelatin-based coating solution for 2 min and incubated in Creative Bioarray’s Culture Complete Growth Medium for 3-5 days.

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Creative Bioarray provides comprehensive and detailed services for stem cell bank characterization to help our customers worldwide in the field of cell banks. We employ multiple assays to assess cell banks from different aspects, including but not limited to PCR, qPCR, next-generation sequencing, and transmission electron microscopy. Rapid and accurate results will be delivered to assist customers in accessing the quality of cell banks as soon as possible.

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Major mammalian cell lines used in the biopharmaceutical industry as host cells for the production of biologics include Chinese hamster ovary (CHO) cells and mouse myeloma cells, including NS0 and Sp2/0 cells. Creative Bioarray provides comprehensive and detailed services for mammalian cell bank characterization to help our customers worldwide in the field of cell banks. We delivered rapid and accurate results to assist customers in accessing the quality of cell banks. Reliable, rapid, and accurate results will be delivered to assist customers in assessing the quality of cell banks.

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As an established leader in the field of cell science, Creative Bioarray's expertise in cell banking is unparalleled. Our QC testing plans meet requirements for cell bank release and are designed to meet regulations with assays validated to GMP standards. Ready-to-use testing schemes may be added to existing strategies or customized for the needs of specific programs.

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Our services not only include hERG inhibition testing but also cover inhibitory assessments of potassium, calcium, and sodium channels, as well as other related channels or receptors. Additionally, we provide "Comprehensive Cardiotoxicity Assessment (CiPA)" and "Langendorff Isolated Perfused Heart Assay" services. These comprehensive and precise assessment methods enable the evaluation of your drug's in vitro cardiotoxicity potential, thereby reducing the risk of development failure due to cardiac safety issues, and consequently minimizing economic losses.

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