In addition, RBCs contain a variety of enzymes that can metabolize many drugs. Thus, the processing of blood samples should be done in accord with a protocol that is based on the results of previous studies, establishing the interaction between RBCs and the drug being developed. Sample protocols should specify the centrifugation time, temperature, and pH conditions, as well as need for addition of enzyme inhibitors. At Creative Bioarray, the red blood cell partitioning assay provides a specific and robust approach to assess these parameters using fresh blood from human and preclinical species.

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