Visual impairment is a major health problem affecting millions of people around the world. Major causes of visual impairment and blindness include cataract, glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy (DR), with cataracts being the leading cause of blindness worldwide. Strategies to develop animal models that closely mirror human ocular diseases are necessary for a better understanding of the underlying causes and simultaneously for the development of novel therapeutic approaches. Recently, zebrafish have been at the leading edge of preclinical therapy development, with their amenability to genetic manipulation facilitating the generation of robust ocular disease models required for large-scale genetic and drug screening programs.

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