Hepatocyte growth factor (HGF) is a diverse protein hormone that is secreted by mesenchymal cells and has biological effects on many cells. HGF binds to its high-affinity receptor c-Met and plays an important role in hepatocyte growth, motility, proliferation, differentiation, and cellular adaptation. HGF's ability to stimulate mitosis, cell motility, and stromal invasion gives it a central role in angiogenesis, HGF plays a central role in angiogenesis, tumorigenesis, and tissue regeneration. In addition, HGF has been associated with a variety of cancers, including lung, pancreatic, thyroid, colon, and breast cancers.

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