LCMS: Transforming Food Safety and Quality Control

The eluent from the LC column is then introduced into the mass spectrometer. Here, the analytes are ionized, most commonly using electrospray ionization (ESI). The ions are then separated based on their mass-to-charge ratio in the mass analyzer. This generates a mass spectrum that is characteristic of each analyte’s molecular structure. The retention time data from Liquid chromatography mass spectrometry (LCMS) is combined with the mass spectral data to provide a complete characterization of each component within the original sample.

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