As life science research advances toward precision and efficiency, researchers face a key methodological decision when probing gene function: Should they choose RNA interference (RNAi) or CRISPR-based gene editing?

Both technologies offer pathways to suppress or alter gene expression, but they differ fundamentally in their mechanisms, effectiveness, and downstream applications. This article explores the strengths and limitations of RNAi and CRISPR, and how each serves different purposes in today’s molecular biology landscape.

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