Exosome is a kind of tiny vesicle secreted by most cells. It has a lipid bilayer structure and distributes in peripheral blood, urine, saliva, ascites, amniotic fluid, and other body fluids. Exosome carries important information such as proteins, lipids, and nucleic acids, especially non-coding RNA (miRNA, lncRNA, circRNA, etc.), which makes it more meaningful. Exosomes not only play an important role in cell-to-cell material and information transmission but also are expected to become early diagnostic markers for a variety of diseases. Exosome RNA sequencing can quickly and efficiently obtain comprehensive information of exosome RNA, which is an ideal means of disease diagnosis and follow-up. At present, researches on RNA based on exosomes mainly focus on miRNA, lncRNA, circRNA, mRNA and other types.
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Creative Biostructure is a world-leading provider of virus-like particles (VLPs). We offer both VLP production services and various VLP products for multiple applications, such as delivery system, vaccine development, and membrane protein expression.

VLPs are non-infectious nanoparticles that can be recombinantly assembled from expressed viral proteins and without the viral genome required for viral replication and infection. Because they are non-infectious, VLPs do not require the same strict biosafety level as competent native viruses. At the same time, they can retain the self-assembling and antigen-presenting capabilities for innovative therapeutics uses. VLP technology has become a successful tool to develop multivalent vaccines against a wide range of infectious and epidemic viruses, such as Zika virus (ZIKV), Ebola virus (EBOV), Chikungunya (CHIKV), Yellow fever virus (YFV), and Japanese encephalitis virus (JEV).
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