Para-Toluenesulfonyl chloride (PTSC) is a chloro derivative of toluene. P-toluenesulfonyl chloride formula (C₇H₇ClO₂S), it is an off white to white crystalline solid commonly used in organic preparation. Structurally, 2 substituents, which are a methyl group (-CH3) and a sulfonyl chloride group (-SO2Cl) at the para position, a benzene group that is admitted as PTSC. Alcohol and amines turn into tosylates and sulfonamides, after a conversion. Further, it is mainly considered as PTSC when it becomes a key intermediate in drugs, dyes, and other fine chemicals manufacturing process.

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