Sal4 is an IgA monoclonal antibody that binds to Salmonella Typhimurium's lipopolysaccharide and recognizes its O5-antigen, thereby preventing the bacteria from causing intestinal invasion. The protective properties of CAM003, an IgG1 binding to a Pseudomonas aeruginosa biofilm component, have been shown in a number of animal models. The heavy, light, and J chains of Sal4 and CAM003 were encoded into human IgA2 (IgA2 mRNA) or IgA1 (IgA1 mRNA), respectively, by the researchers. Then, in vivo and in vitro, they contrasted these with rIgA to assess mRNA platforms' capacity to generate strong, protective monoclonal antibodies in mucosal secretions. The results of the study demonstrated that the IgA generated by mRNA had a much longer serum half-life and a more natural glycosylation spectrum than rIgA.
For more: https://non-igg-ab.creativ...