Current Influenza Therapeutics Approaches for Influenza

Influenza, commonly known as flu, is an infectious disease caused by RNA viruses of the family Orthomyxoviridae. The flu viruses mostly affect the respiratory tract and can lead to severe complications like pneumonia. While vaccination remains the best strategy for flu prevention, research on effective therapeutics is crucial for timely treatment.

Adamantanes
Adamantanes like amantadine and rimantadine target the M2 ion channel protein of influenza A viruses to inhibit viral uncoating inside the host cell. But due to their limited effectiveness and high resistance rates today, adamantanes are no longer recommended as first-line antivirals for influenza A treatment by public health agencies. Most currently circulating influenza A viruses are resistant to adamantanes.

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