Advances in Infectious Disease Therapeutics: New Developments in Targeted Antibiotic Discovery

One promising class is inhibitors of the bacterial biosynthesis of folate, an essential vitamin for bacteria. By blocking certain enzymes involved in folate synthesis, these drugs kill bacteria without affecting human folate pathways that are different. Early clinical trials show they effectively treat multidrug-resistant bacterial infections with a low risk of side effects or resistance emerging. Researchers continue optimizing these drugs' properties like pharmacokinetics and spectrum of activity.

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