Atopic dermatitis (AD) is a skin disease that is genetically prone to chronic recurrence and high itching caused by the destruction of the epidermal barrier and related immune disorders. Most AD is onset in early childhood and has characteristics that depend on age distribution. The disease is usually accompanied by elevated IgE levels, increased peripheral blood eosinophils, and other allergic symptoms. Creative Proteomics can provide you with a one-stop atopic dermatitis cytokine solution. https://cytokine.creative-...

Autoimmunity is a phenomenon in which the body's immune system develops an immune response to its own antigens and produces autoantibodies or auto-sensitizing lymphocytes. When autoimmunity is abnormal, autoantibodies and reactive lymphocytes attack the tissues or airways that express the target antigen, causing autoimmune disease (AID). The pathogenesis of autoimmune diseases is very complex, but the activation of auto-reactive T cells and B cells is an inevitable part of the development of disease, and the detection of Cytokines in Autoimmune Disease produced by T cells reflects the degree of activation of T cells to a certain extent. Different cytokines are involved in different autoimmune disease processes, and the role of the same cytokine varies in different autoimmune diseases. https://cytokine.creative-...

Pelargonidin is a natural plant pigment belonging to the group of compounds known as anthocyanins. It is responsible for the red, orange, or pink coloration observed in various fruits, flowers, and vegetables. Pelargonidin is widely distributed in nature and is particularly abundant in berries such as strawberries, raspberries, and cranberries. https://metabolomics.creat...

"What is butanoic acid?
Propanoate metabolism depicts the metabolism of propionic acid. Propionic acid basically stems from the production of the acid by either gut or skin microflora. Propanoate is converted into propanol adenylate via propionyl-CoA synthetase and acetyl-CoA synthetase in mitochondrial. The propionyl adenylate then is converted into propionyl coenzyme A (propionyl-CoA), which is carboxylated into D-methylmalonyl-CoA via propionyl-CoA carboxylase. " https://metabolomics.creat...

In IEF, proteins migrate to their respective pI and remain stabilized. To conduct successful IEF, stable and linear pH gradients are important. Creative Proteomics provides a high-resolution IEF capable of separating proteins with different pI point. Depending on your samples, different antibodies, antigens, and enzymes will be employed to ensure the successful fractionation. Buffers and ampholyte conditions will also be optimized to separate proteins across a broad range of pH. https://www.creative-prote...

PEGylation is a process of attaching one or more molecules of polyethylene glycol (PEG) to target biomolecules including peptides, proteins and oligonucleotide. It is a vital modification used in biopharmaceuticals to facilitate the functions of therapeutic proteins and peptides. PEGylation of proteins improves pharmacokinetic and pharmacodynamic properties of proteins. PEG has been approved as pharmaceutical excipient for injection by FDA. https://www.creative-prote...

Water-soluble vitamins (WSVs), encompassing the B-complex vitamins and vitamin C, represent a category of organic compounds essential for sustaining human life. They actively participate in the regulation of physiological processes within the body and serve as crucial bioactive substances for maintaining human health. Our company offers a single injection quantitative determination of multiple water-soluble vitamins. This vitamins water soluble method provides strong specificity, high sensitivity, and reliable stability. https://www.creative-prote...

The tricarboxylic acid (TCA) cycle, also known as the citric acid cycle or the Krebs cycle, is a crucial metabolic pathway in all aerobic organisms. And the TCA cycle plays a pivotal role in I) Energy production: the catabolism of carbohydrates, lipids, and proteins for ATP production. II) Intermediary metabolism: in addition to producing energy, the TCA cycle also serves as a central hub for the interconversion of metabolic intermediates. With over a decade of experience in metabolomics services, Creative Proteomics can provide superior service for analyzing TCA cycle metabolites. https://www.creative-prote...

Tandem affinity purification (TAP) is a rapid technique used to study protein-protein interactions in vivo. Through two steps of specific affinity purification, TAP allows for the rapid isolation of proteins that interact with the target protein under physiological conditions. Originally developed for use in yeast, the TAP method has rapidly evolved due to its versatility, efficiency, high purity, and low false positives. It has since been successfully applied to the study of protein interactions in various other organisms, including mammals and plants. https://www.creative-prote...

Our professional platform can provide cardiovascular biomarker analysis of inflammation and oxidative stress to accelerate the identification/prediction of relevant mechanisms of the occurrence and development of CVD, and promote the development of targeted therapeutic drugs. The samples we can detect are not limited to human samples, but also include other species. https://cytokine.creative-...

Redness, hot pain as well as sepsis, are symptoms of the pathological process of infectious inflammation, a phenomenon that occurs with the participation of mediators produced by a large number of inflammatory cells, where cytokines are also involved. Cytokines are biologically active low molecular weight proteins or peptides secreted by various cells that regulate cell growth and differentiation, immune function, inflammation and wound healing. When pathogens invade or the body ages, inflammation cytokine signalling activate the body's immune system to defend against invaders. And when invaders are eliminated and the body needs to regain stability, anti-inflammatory cytokines are secreted. The constant interaction and balance between inflammatory and anti-inflammatory cytokines is an important part of the human immune system. https://cytokine.creative-...

The carbohydrate metabolism provides a versatile tool to assess medical risks, identify novel biomarkers and gain insight to molecular mechanisms of disease by analysing hundreds of carbohydrate metabolites in individual’s samples. The carbohydrate metabolism analysis has been applied in a wide range of fields including biomarker discovery, human disease research, clinical diagnostics, drug discovery, food safety, nutrition and systems biology. With integrated array of separation, characterization, identification and quantification experience, Creative Proteomics provides reliable, rapid and cost-effective analysis of carbohydrates services for your various scientific purposes. https://metabolomics.creat...

What are carotenoids? Carotenoids, a diverse group of pigments found in various organisms, exhibit a remarkable array of colors ranging from vibrant reds and oranges to bright yellows. These visually appealing compounds have captured the attention of scientists and researchers for their intriguing properties and multifaceted roles. In addition to their visual impact, carotenoids also possess significant nutritional and health benefits, making them a subject of extensive analysis and study. https://metabolomics.creat...

Creative Proteomics offers a comprehensive protein intact mass analysis service using advanced mass spectrometry techniques to ensure the safety and efficacy of biopharmaceuticals. Our state-of-the-art mass spectrometry instruments and experienced scientists can accurately determine the molecular weight of intact proteins to help identify impurities, modifications, and structural changes. https://www.creative-prote...

Protein molecules are biological macromolecules formed by many amino acids connected by peptide bonds. Physiologically functional proteins in the body are all ordered structures. Each protein has a certain percentage of amino acid mass, the sequence of amino acids, and the specific arrangement position of the peptide chain space. Therefore, the protein molecular structure composed of the sequence of amino acids and the spatial arrangement of peptide chains is the structural basis for each protein to have a unique physiological function. https://www.creative-prote...