Atopic dermatitis (AD) is a skin disease that is genetically prone to chronic recurrence and high itching caused by the destruction of the epidermal barrier and related immune disorders. Most AD is onset in early childhood and has characteristics that depend on age distribution. The disease is usually accompanied by elevated IgE levels, increased peripheral blood eosinophils, and other allergic symptoms. Creative Proteomics can provide you with a one-stop atopic dermatitis cytokine solution. https://cytokine.creative-...

Autoimmunity is a phenomenon in which the body's immune system develops an immune response to its own antigens and produces autoantibodies or auto-sensitizing lymphocytes. When autoimmunity is abnormal, autoantibodies and reactive lymphocytes attack the tissues or airways that express the target antigen, causing autoimmune disease (AID). The pathogenesis of autoimmune diseases is very complex, but the activation of auto-reactive T cells and B cells is an inevitable part of the development of disease, and the detection of Cytokines in Autoimmune Disease produced by T cells reflects the degree of activation of T cells to a certain extent. Different cytokines are involved in different autoimmune disease processes, and the role of the same cytokine varies in different autoimmune diseases. https://cytokine.creative-...

Pelargonidin is a natural plant pigment belonging to the group of compounds known as anthocyanins. It is responsible for the red, orange, or pink coloration observed in various fruits, flowers, and vegetables. Pelargonidin is widely distributed in nature and is particularly abundant in berries such as strawberries, raspberries, and cranberries. https://metabolomics.creat...

"What is butanoic acid?
Propanoate metabolism depicts the metabolism of propionic acid. Propionic acid basically stems from the production of the acid by either gut or skin microflora. Propanoate is converted into propanol adenylate via propionyl-CoA synthetase and acetyl-CoA synthetase in mitochondrial. The propionyl adenylate then is converted into propionyl coenzyme A (propionyl-CoA), which is carboxylated into D-methylmalonyl-CoA via propionyl-CoA carboxylase. " https://metabolomics.creat...

In IEF, proteins migrate to their respective pI and remain stabilized. To conduct successful IEF, stable and linear pH gradients are important. Creative Proteomics provides a high-resolution IEF capable of separating proteins with different pI point. Depending on your samples, different antibodies, antigens, and enzymes will be employed to ensure the successful fractionation. Buffers and ampholyte conditions will also be optimized to separate proteins across a broad range of pH. https://www.creative-prote...

PEGylation is a process of attaching one or more molecules of polyethylene glycol (PEG) to target biomolecules including peptides, proteins and oligonucleotide. It is a vital modification used in biopharmaceuticals to facilitate the functions of therapeutic proteins and peptides. PEGylation of proteins improves pharmacokinetic and pharmacodynamic properties of proteins. PEG has been approved as pharmaceutical excipient for injection by FDA. https://www.creative-prote...

Water-soluble vitamins (WSVs), encompassing the B-complex vitamins and vitamin C, represent a category of organic compounds essential for sustaining human life. They actively participate in the regulation of physiological processes within the body and serve as crucial bioactive substances for maintaining human health. Our company offers a single injection quantitative determination of multiple water-soluble vitamins. This vitamins water soluble method provides strong specificity, high sensitivity, and reliable stability. https://www.creative-prote...

The tricarboxylic acid (TCA) cycle, also known as the citric acid cycle or the Krebs cycle, is a crucial metabolic pathway in all aerobic organisms. And the TCA cycle plays a pivotal role in I) Energy production: the catabolism of carbohydrates, lipids, and proteins for ATP production. II) Intermediary metabolism: in addition to producing energy, the TCA cycle also serves as a central hub for the interconversion of metabolic intermediates. With over a decade of experience in metabolomics services, Creative Proteomics can provide superior service for analyzing TCA cycle metabolites. https://www.creative-prote...

Tandem affinity purification (TAP) is a rapid technique used to study protein-protein interactions in vivo. Through two steps of specific affinity purification, TAP allows for the rapid isolation of proteins that interact with the target protein under physiological conditions. Originally developed for use in yeast, the TAP method has rapidly evolved due to its versatility, efficiency, high purity, and low false positives. It has since been successfully applied to the study of protein interactions in various other organisms, including mammals and plants. https://www.creative-prote...

Our professional platform can provide cardiovascular biomarker analysis of inflammation and oxidative stress to accelerate the identification/prediction of relevant mechanisms of the occurrence and development of CVD, and promote the development of targeted therapeutic drugs. The samples we can detect are not limited to human samples, but also include other species. https://cytokine.creative-...

Redness, hot pain as well as sepsis, are symptoms of the pathological process of infectious inflammation, a phenomenon that occurs with the participation of mediators produced by a large number of inflammatory cells, where cytokines are also involved. Cytokines are biologically active low molecular weight proteins or peptides secreted by various cells that regulate cell growth and differentiation, immune function, inflammation and wound healing. When pathogens invade or the body ages, inflammation cytokine signalling activate the body's immune system to defend against invaders. And when invaders are eliminated and the body needs to regain stability, anti-inflammatory cytokines are secreted. The constant interaction and balance between inflammatory and anti-inflammatory cytokines is an important part of the human immune system. https://cytokine.creative-...

The carbohydrate metabolism provides a versatile tool to assess medical risks, identify novel biomarkers and gain insight to molecular mechanisms of disease by analysing hundreds of carbohydrate metabolites in individual’s samples. The carbohydrate metabolism analysis has been applied in a wide range of fields including biomarker discovery, human disease research, clinical diagnostics, drug discovery, food safety, nutrition and systems biology. With integrated array of separation, characterization, identification and quantification experience, Creative Proteomics provides reliable, rapid and cost-effective analysis of carbohydrates services for your various scientific purposes. https://metabolomics.creat...

What are carotenoids? Carotenoids, a diverse group of pigments found in various organisms, exhibit a remarkable array of colors ranging from vibrant reds and oranges to bright yellows. These visually appealing compounds have captured the attention of scientists and researchers for their intriguing properties and multifaceted roles. In addition to their visual impact, carotenoids also possess significant nutritional and health benefits, making them a subject of extensive analysis and study. https://metabolomics.creat...

Creative Proteomics offers a comprehensive protein intact mass analysis service using advanced mass spectrometry techniques to ensure the safety and efficacy of biopharmaceuticals. Our state-of-the-art mass spectrometry instruments and experienced scientists can accurately determine the molecular weight of intact proteins to help identify impurities, modifications, and structural changes. https://www.creative-prote...

Protein molecules are biological macromolecules formed by many amino acids connected by peptide bonds. Physiologically functional proteins in the body are all ordered structures. Each protein has a certain percentage of amino acid mass, the sequence of amino acids, and the specific arrangement position of the peptide chain space. Therefore, the protein molecular structure composed of the sequence of amino acids and the spatial arrangement of peptide chains is the structural basis for each protein to have a unique physiological function. https://www.creative-prote...

Sample preparation and extraction of steroids is by either liquid-liquid extraction (LLE) or supported liquid extraction (SLE) followed by an on-line 2D polishing extraction. Target steroid analytes are chromatographically separated on a reverse-phase (RP) column. All analytes and Internal Standards are measured by ESI ionization--pos and/or neg polarity (analyte dependent). Creative Proteomics provide customer-tailored service with rapid peptide steroids analysis procedures and easy to read report, to speed up your scientific research. https://www.creative-prote...

Protein Sequence Analysis is the process of subjecting a protein or peptide sequence to one of a wide range of analytical methods to study its features, function, structure, or evolution. Methodologies used include sequence alignment, searches against biological databases, and other methods. Since the development of methods of high-throughput production of protein sequences, the rate of addition of new sequences to the databases increased exponentially. https://www.creative-prote...

"what is a phytohormone?
Plant hormones, also known as phytohormones, are endogenously synthesized compounds in plants. They play crucial roles in regulating responses to external environmental changes, modulating growth states, resisting adverse conditions, and maintaining essential metabolic processes. Phytohormones are of significant importance in plant growth and development, pest and disease resistance, breeding, and protection. Consequently, there is an increasing interest in metabolomics techniques specifically designed for the targeted quantification of plant hormones." https://www.creative-prote...

Sphingolipids are an important part of neurons and myelin sheath. Mainly divided into hexosylceramide (HexCer), lactosylceramide (LacCer), sphingosine (Sph), dihydrosphingosine (DhSph) and dihydroceramide (DhSph). Sphingolipid levels will change under different physiological, pathological and disease conditions. Creative Proteomics can provide one-stop hexosylceramides analysis service. We have LC-MS/MS and GC-MS/MS technologies to provide high-resolution and reliable lipidomics identification and quantification services. https://lipidomics.creativ...

The combination of MS instrument and liquid chromatography (LC) can effectively separate target lipid molecules from complex samples. High-quality and accurate lipid level analysis helps to study the changes in the content of lysoPAF under physiological and other pathological conditions, and accelerate the analysis of biomarkers and related disease mechanisms. With extensive experience and state-of-the-art technologies, Creative Proteomics use highly sensitive LC-MS/MS method for the rapid identification and quantification of lysoPAF in different sample types, which can satisfy the needs of academic and industrial study. https://lipidomics.creativ...

To facilitate sheep-related research in animal husbandry and animal medicine, Creative Proteomics has the ability to provide you with customized sheep cytokine/chemokine panel assays. Based on Luminex xMAP technology, we can measure multiple inflammatory biomarkers simultaneously. Our panels can simultaneously quantify multiple cytokine and marker proteins in serum, plasma and tissue culture supernatant samples. https://cytokine.creative-...

"Creative Proteomics can simultaneously quantitatively detect diabetes cytokines assay and protein through a variety of technologies, and provide higher sensitivity and a wider detection range. We mainly provide the Luminex cytokine detection platform. Luminex uses fluorescently encoded microspheres with specific antibodies to different target molecules. The different microspheres can be combined freely to a certain extent so that up to 100 analytes can be tested multiple times simultaneously in a single experiment.
" https://cytokine.creative-...

Amino acids are biologically important organic compounds, consisting of amino (-NH2) and carboxyl (-COOH) functional groups, as well as side chains connected to each amino acid. Creative Proteomics developed an amino acid analysis by LC-MS platform for absolute quantitative detection of 130+ amino acids and their derivatives. https://metabolomics.creat...

Lipid metabolism involves the synthesis and breakdown of lipids in cells, playing crucial roles in energy storage, cell membrane construction, and signaling. Analysis of lipid metabolism is essential for understanding human health, drug development, and biology. https://metabolomics.creat...

Protein N-myristoylation is a universal post-translational modification in eukaryotes catalyzed by the enzyme N-myristoyltransferase (NMT), which transfers myristate from myristoyl coenzyme A (Myr-CoA) to the N-terminal glycine of a wide range of substrate proteins, it has been involved in the progression and development of a range of human diseases, such as cancer1, epilepsy, Alzheimer’s disease, Noonan-like syndrome and viral and bacterial infections. Both NMT1 and NMT2 of human NMT isozymes are conveyed in most tissues. N-myristoylation is certainly surpassed by proteolysis to show an N-terminal glycine, the only completely conserved motif across all known NMT substrates. This may happen either co-translationally when methionine aminopeptidase (MetAP) acts on an N-terminal ‘MG’ motif at the ribosome, or post-translationally at an internal site. Besides the importance in health and disease of N-myristoylation, direct identification of the N-myristoylated proteome in cells has been limited to non-native low-throughput systems, for example, over-expression of artificial protein constructs. N-terminally myristoylated proteins are related to many kinds of cellular processes, which includes proliferation, differentiation, and apoptosis, and have been shown to be essential for embryogenesis. https://www.creative-prote...

The molecular weight of protein is an important analytical parameter in biochemistry. It is necessary to determine the molecular weight of recombinant proteins and key subunits by a fast and accurate method. Accurate quality determination allows us to assess the correctness of the primary protein sequence, the presence of mutations and post-translational modifications, possible degradation, homogeneity, and the degree of isotope incorporation during labeling. Creative Proteomics is equipped with both of these mass spectrometry systems. Whether you need to confirm the protein spectrum or peptide fingerprint analysis and protein identification of a variety of protein molecular weight analysis, Creative Proteomics can meet your needs to provide customized solutions. https://www.creative-prote...

Lipids are hydrophobic or amphipathic small molecules which include fats, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E and K), monoglycerides, diglycerides and phospholipids. The important roles of lipids in biological physiology are evident not only in energy storage and structural components of cellular membranes, but also in signal transduction, membrane trafficking and morphogenesis. lipid content analysis is the synthesis and degradation of lipids in cells, consisting of the breakdown or storage of fats for energy and the synthesis of structural and functional lipids like those involved in the construction of cell membranes. https://metabolomics.creat...

Inositol phosphates contain multiple phosphorylated derivatives and individual PIPs can contain different fatty acid chains, resulting in structural complexity. Creative Proteomics has built a dedicated analytical platform to provide you with qualitative and quantitative analysis of inositol phosphates. Based on ion chromatography separation techniques, we are able to accurately determine the total amount of phosphorylated derivatives. Based on LC/MS technology, we are able to quantify inositol phosphate pathway containing specific fatty acid chain structures. https://metabolomics.creat...

Starch is a polymeric carbohydrate consisting of a large number of glucose units connected by glycosidic bonds. Similarly, sucrose is a kind of carbohydrate and composed of two monosaccharides: glucose and fructose. Basically, the starch and sucrose metabolism begin with D-fructose that interacts with a D-glucose in a reversible reaction through a maltodextrin glucosidase. By multiple procedures, the metabolism of starch and sucrose produce several important intermediates like glucose-6-phosphate and fructose-6-phosphate, which interact with other metabolic pathways including glycolysis and gluconeogenesis. Creative Proteomics has advanced mass spectrometry instrumentation and a team of bioinformatic analysts to provide starch analysis method. https://metabolomics.creat...

Apoptosis plays an important role in the immune system, which is closely related to intracellular homeostasis, T cell aggregation, death of reactive lymphocytes and cytotoxic response of target cells. At present, it has been found that eukaryotic cell apoptosis mainly has the following pathways: 1. Cell receptor-mediated external apoptotic pathways; 2. Internal mitochondrial pathway; 3. B-granase mediated apoptosis pathway; 4. Endoplasmic reticulum stress pathway mediates apoptosis. The detection of cytokines related to apoptosis helps to study apoptosis and the physiological or pathological processes involved. Creative Proteomics can simultaneously quantitatively detect apoptosis and proinflammatory cytokines through a variety of technologies, and provide higher sensitivity and a wider detection range. https://cytokine.creative-...