Immunohistochemistry is the study of localization, characterization, and relative quantification of peptides and proteins in tissue cells by applying the principle of antigen-antibody reaction, i.e., specific binding of antigen and antibody, through chemical reactions that allow the color development of chromogenic agents such as fluorescein, enzymes, metal ions, and isotopes that label antibodies to identify them. https://www.bioimagingtech...

CD BioSciences is a biotechnology company with a high-resolution 3D bioprinting technology platform dedicated to providing bioink products and its customization services. CD BioSciences can offer the following hyaluronic acid-based 3D bioprinting bioinks for you to choose from. https://www.3dmicroflu.com...

Acetylation is one of the major protein modifications in cells, where the acetyl group from acetyl coenzyme A (acetyl-CoA) is transferred to a polypeptide chain. Protein acetylation can occur at N-terminal as a co-translational covalent modification by N-terminal acetyltransferases (NATs), or on lysine as a reversible post-translational modification (PTM). Like phosphorylation, acetylation also affects protein function by altering the properties of proteins such as hydrophobicity, solubility, protein conformation and affinity with other macromolecules. https://www.cd-biosciences...

Protein is a complex organic compound composed of amino acids. Due to the hydrophilicity, hydrophobicity, positive charge, negative charge and other characteristics of amino acid residues, it can be folded into a precise 3D structure through the interaction between the residues. The sequence of amino acids determines the unique 3D structure of each protein and its specific functions. Protein participates in almost every process in the cell and is necessary to maintain the structure and function of human tissues and organs. Protein folding errors can induce a variety of degenerative diseases, such as Parkinson's disease, Alzheimer's disease, frostbite, and senile heart failure. Therefore, imaging analysis of the folding process of proteins is of great significance for the early diagnosis and treatment of diseases. https://www.bioimagingtech...

At present, metal 3D printing occupies a considerable part of the 3D printing industry. High-temperature alloy (also known as super alloy) is a common metal 3D printing material. Long-term work at high temperatures (above 600℃) can bear a certain stress while also resisting corrosion and antioxidant effects. The super alloy mainly includes three types: nickel, cobalt, and iron-based. Nickel super alloy (nickel-based substrates, generally greater than 50%) occupies the vast majority. As shown in Fig. 1, the researchers used IN718 nickel super alloy material to produce an upgraded fuel injector through 3D printing technology. https://www.3dmicroflu.com...

Cell signaling plays a central role in modern life science research. Intercellular communications are carried out by small molecules interacting with their targets at the cell membrane followed by activation of a series of intracellular processes which eventually affect cell growth and survival. There are a limited number of key signaling pathways that operate during development, including Notch signaling pathway, TGF-β signaling pathway, Wnt signaling pathway, and Hedgehog signaling pathway. https://www.cd-biosciences...

CD BioSciences has been a trusted biotechnology company and our services in bio-3D printing have been well-received by our customers. The team of experts from CD BioSciences provides various types of in vitro model construction services based on the high-resolution 3Dmicroflu™ technology platform, covering almost all aspects of life science research. Here, the advantages and applications of the 3Dmicroflu™ technology platform for the construction of non-alcoholic steatohepatitis models are demonstrated below. https://www.3dmicroflu.com...

Cells are the basic units of living organisms and have a variety of important functions that enable organisms to function properly and sustain life. Different types of cells have specific functions to meet the needs of different tissues and to maintain the normal life activities of an organism. Cell function imaging can be used to observe and analyze the functions of living cells, usually by visualizing and recording intracellular biological processes, and molecular interactions, and quantifying many metrics to reveal information about the cell's function. In addition to understanding the physiological mechanisms of cells, cell function imaging can also obtain information related to the mechanisms of disease occurrence and the actions and effects of drugs. https://www.bioimagingtech...

Proteostasis is the dynamic regulation of protein homeostasis, where all the cellular pathways govern the production, folding, trafficking and degradation of proteins. Pathways to ensure proteostasis in different subcellular compartments are defined as unfolded protein responses (UPRs), which have evolved in the cytosol as cytosolic heat shock response (HSR), endoplasmic reticulum as UPRER and mitochondria as UPRmt.

Dysfunction of proteostasis signaling pathways has been implicated in a variety of age-related diseases including neurodegenerative diseases (e.g., Alzheimer's disease), metabolic diseases (e.g., diabetes), inflammatory diseases, and cancer.

As a trusted CRO, CD BioSciences provides a comprehensive panel of solutions covering all aspects of life science research, including proteostasis & UPR. https://www.cd-biosciences...

Time-lapse imaging technology is a powerful, versatile and continuously developed imaging tool that can take continuous images at regular points in time to capture the dynamics of the things being observed. Live cell time-lapse imaging can monitor the response of live cells during a certain period of time and generate a large amount of image-based information to quantify the behavior of cell populations. https://www.bioimagingtech...

Nylon (PA), also known as polyamide, is a high molecular polymer containing amide groups in the repeating unit on the main chain of the molecular, indispensable materials for the injection industry. Nylon materials are also widely used in the 3D printing market. As shown in Fig. 1, the 3D printed prosthetic hand could perform power, pinch, and tripod grasps, and the tendons were 3D printed in nylon. https://www.3dmicroflu.com...

A multicellular organism develops from a single cell (zygote) into a collection of cells organized into tissues and organs through cell division, cell differentiation, body axis formation, tissue and organ development. Developmental biology is a branch of life science which studies the genetic control of cell growth, differentiation, migration and survival. It also includes the investigation of processes that generate an organism's heterogeneous shapes, size, and structural features.

As a trusted CRO, CD BioSciences provides a comprehensive panel of solutions covering all aspects of life science research, including developmental biology. https://www.cd-biosciences...

DNA / RNA - protein interactions are critical to all organisms, especially in the regulation of DNA replication, transcription and repair, and RNA transport and translation. At present, a variety of in vivo and in vitro methods have been developed to analyze DNA / RNA - protein interactions, such as affinity purification schemes, EMSA and chromatin purification methods, but they cannot perform single-molecule real-time imaging analysis and effectively analyze the mechanism of DNA / RNA - protein interaction. The combination of fluorescence probe and microscope provides an effective tool for researchers to study its interaction mechanism. https://www.bioimagingtech...

Boron carbide (B4C) is an inorganic nonmetallic material with excellent performance, which is synthesized at high temperatures by the combination of boron and carbon.The hardness of B4C materials are second only to diamond and cubic boron nitride, and thry have excellent chemical and physical properties. With the explosive development of 3D printing technology, a wider range of materials can be printed now. Recently, B4C materials have also begun to be applied in the field of 3D printing. As shown in Fig. 1, a qualified 3D printing (FDM) test piece with B4C-PEEK composites. https://www.3dmicroflu.com...

The endoplasmic reticulum (ER) is a continuous membrane system within the cytoplasm of eukaryotic cells. It is an important site for the synthesis, folding, modification, and transport of proteins. Perturbation of ER homeostasis through the accumulation of unfolded or misfolded proteins results in a stress condition, i.e., ER stress, and activates unfolded protein response (UPR). ER UPR (UPRER) instigates transcriptional and translational responses to relieve ER stress.

In animals, the ER UPR signaling pathway is initiated by three membrane-associated stress sensor proteins: inositol requiring enzyme 1α/β (IRE1), PKR-like ER kinase (PERK), and activating transcription factor 6α/β (ATF6). https://www.cd-biosciences...